Call for submissions for Leonberger Cancer Research
MAPPING GENETIC RISK FACTORS FOR OSTEOSARCOMA AND HEMANGIOSARCOMA IN LEONBERGERS
CALL FOR MORE SAMPLES - September 13, 2016
With support from the Leonberger Health Foundation and in collaboration with several
laboratories in the United States and Europe, Professor Kerstin Lindblad-Toh’s groups at Uppsala
University in Sweden and Broad Institute in the US aim at identifying genetic risk factors that
predispose Leonbergers to Osteosarcoma (OSA) and Hemangiosarcoma (HSA). Thanks to
Leonberger owners and clubs who submitted samples to our participating centers, we have made
significant progress in collecting and characterizing samples from healthy and OSA/HSA-affected
Leonbergers, and we have generated genomics data needed to look for genetic risk factors
predisposing to these diseases. In the case of OSA, preliminary genome-wide association
analyses of genotyped Leonberger cases and controls are promising in identifying genome-wide
significant markers, but including more samples in the analysis will definitely strengthen the
analysis. In the case of HSA, preliminary analyses did not reveal any genome-wide significant
associations, which we attribute to the smaller sample size of HSA cases and the fact that many of
them were not pathologically confirmed to be HSA. While we will do the best we can with the
data we have, it is critical that we receive more confirmed HSA case samples as soon as possible.
Therefore, our research would greatly benefit from receiving more samples for Leonbergers
diagnosed with OSA and HSA, especially those with a confirmed diagnosis, and also samples for
healthy controls. Since our two groups are in constant communication and share samples and
data, we invite the senders to ship the samples to the center located most conveniently to them
(see addresses below). Samples should be accompanied by the consent form appropriate for each
center (see next pages) and any additional information or medical records (if available).
Swedish Agricultural University
Animal breeding and genetics
ATTN: Susanne Gustafsson
Leonberger OSA/HSA
Box 7023
S-750 07 Uppsala
SWEDEN
(Please, notify us at [email protected] that a sample is on its way)
OR
Broad Institute
Attn: Michele Koltookian 6112-A
Leonberger OSA/HSA
415 Main Street
Cambridge, MA 02142
USA
(Please, notify us at [email protected] that a samples is on its way)
Corresponding consent forms:
• Consent Form for UppsalaUniversity/SLU Sweden (pages 2-3)
• Consent Form for Broad Institute US (pages 4-5)
WE THANK LEONBERGER OWNERS, CLUBS AND ORGANIZATIONS FOR THEIR
CONTINUED SUPPORT AND INTEREST IN OUR RESEARCH
PLEASE DOWNLOAD THE FILE TO GET THE CONSENT FORMS HERE:
| callforsamples_leonbergerunion_2016-09-13.pdf |
Good summary of some recent research in an article here: https://www.avma.org/News/JAVMANews/Pages/171201a.aspx
